Vitamin K Deficiency in the Hospitalized Patient-- Are we Underestimating the Prevalence?
نویسنده
چکیده
Vitamin K is necessary for synthesis of coagulation factors II (prothrombin), VII, IX and X in the liver. In the absence of vitamin K, the liver will synthesize inactive precursor proteins known as proteins induced by the absence of vitamin K (PIVKA's). Because vitamin K is fat-soluble, it can only be absorbed from the intestine in the presence of bile salts. The body's capacity to store vitamin K is very low and the half-life of the vitamin Kdependent coagulation factors is short [1]. Because of this, deficiency can occur quickly if the intake is not sufficient.
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